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  • Title: Systemic lupus erythematosus induced by isoniazid.
    Author: Salazar-Páramo M, Rubin RL, García-De La Torre I.
    Journal: Ann Rheum Dis; 1992 Sep; 51(9):1085-7. PubMed ID: 1417144.
    Abstract:
    The case is described of a 73 year old man who presented with a lupus-like syndrome related to treatment with isoniazid and had IgG antinuclear antibodies against the nucleo-histone complex (H2A-H2B)-DNA. After a short course of treatment with prednisone and discontinuation of isoniazid the patient's lupus symptoms resolved and a gradual decrease in antibodies to (H2A-H2B)-DNA occurred. This case suggests that isoniazid is capable of inducing an autoantibody specificity associated with drug related lupus.
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