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  • Title: ALKYLATION OF SYNTHETIC POLYNUCLEOTIDES.
    Author: LUDLUM DB, WARNER RC, WAHBA AJ.
    Journal: Science; 1964 Jul 24; 145(3630):397-9. PubMed ID: 14172601.
    Abstract:
    The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine synthesis.
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