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  • Title: [Synthesis of oligodeoxyribonucleotides containing 5-fluoro-2'-deoxyribocytidine].
    Author: Kubareva EA, Romanova EA, Oretskaia TS, Gromova ES, Shabarova ZA.
    Journal: Bioorg Khim; 1992 May; 18(5):748-50. PubMed ID: 1417995.
    Abstract:
    A synthesis of the phosphoroamidite derivative of 5-fluoro-2'-deoxycytidine which allows one to introduce the modified nucleoside residue into the 5'-position of the oligodeoxyribonucleotide by the standard solid phase phosphoroamidite method, has been carried out. Oligonucleotides with 5-fluoro-2'-deoxycytidine residues in various positions of the DNA strand are obtained by the combination of chemical and enzymatic syntheses.
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