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  • Title: New analogues of Cucurbita maxima trypsin inhibitor III (CMTI III) with simplified structure.
    Author: Rolka K, Kupryszewski G, Rózycki J, Ragnarsson U, Zbyryt T, Otlewski J.
    Journal: Biol Chem Hoppe Seyler; 1992 Oct; 373(10):1055-60. PubMed ID: 1418676.
    Abstract:
    Seven new analogues of trypsin inhibitor CMTI III were obtained by solid-phase peptide synthesis. Three analogues contained only two, instead of three, disulfide bridges, whereas the molecules of the next four analogues were shortened at the N- and/or C-terminus. The elimination of one disulfide bridge in CMTI III induces a decrease in the association equilibrium constants by 6-7 orders of magnitude, whereas the removal of one, two or three amino-acid residues at the N- and/or C-terminus does not significantly affect the activity.
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