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  • Title: Behavior of sperm nuclei incorporated into parthenogenetic mouse eggs prior to the first cleavage division.
    Author: Maleszewski M.
    Journal: Mol Reprod Dev; 1992 Oct; 33(2):215-21. PubMed ID: 1418992.
    Abstract:
    When artificially activated mouse eggs are inseminated in the middle of the first cell cycle, sperm nuclei remain condensed until the first mitosis. During mitosis of the first cleavage division sperm nuclei decondense, subsequently recondense and are passively displaced to the daughter blastomeres. In the 2-cell embryos sperm nuclei form interphase nuclei which are able to replicate DNA and to condense into discrete chromosomes during the following mitotic division. These observations suggest that the mitotic cytoplasm of 1-cell embryos creates similar conditions for the transformation of sperm nuclei into male pronuclei as the cytoplasm of metaphase II oocytes.
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