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  • Title: AMINO ACIDS: INCORPORATION INTO ALPHA- AND BETA-CHAINS OF HEMOGLOBIN BY NORMAL AND THALASSEMIC RETICULOCYTES.
    Author: HEYWOOD JD, KARON M, WEISSMAN S.
    Journal: Science; 1964 Oct 23; 146(3643):530-1. PubMed ID: 14190243.
    Abstract:
    After incubation of reticulocytes with radioactive amino acid, the specific activity of the beta-chain of globin from the blood of patients with thalassemia was consistently lower than that of the alpha-chain. In subjects without this disorder, the specific activity of the beta-chain was always equal to or higher than that of the alpha-chain.
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