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  • Title: INDUCTION OF SEVERAL ADAPTIVE ENZYMES BY ACTINOMYCIN D.
    Author: ROSEN F, RAINA PN, MILHOLLAND RJ, NICHOL CA.
    Journal: Science; 1964 Oct 30; 146(3644):661-3. PubMed ID: 14191708.
    Abstract:
    Although actinomycin D has been used to prevent protein synthesis in experiments of several hours' duration, its effects on the synthesis of adaptive enzymes which are induced over a period of several days have received less attention. Treatment of young rats with doses of actinomycin D, which permitted survival for a period of 5 days, resulted in marked increases in the activities of four hepatic enzymes known to be induced by cortisol: alanine transaminase, tyrosine transaminase, serine dehydrase, and tryptophan pyrrolase. Actinomycin D also induced responses of two of these enzymes in adrenalectomized rats.
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