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  • Title: SEROLOGICAL RESPONSES OF MAN TO TYPHOID VACCINES.
    Author: BENENSON AS.
    Journal: Bull World Health Organ; 1964; 30(5):653-62. PubMed ID: 14196813.
    Abstract:
    Study of the serological responses in man to typhoid vaccines tested in several WHO-sponsored controlled field trials in British Guiana, Poland and Yugoslavia has not indicated any correlation between the level of Vi and O antibodies elicited and the effectiveness of the vaccines. Instead, the more effective vaccines have elicited significantly greater H-antibody responses; but a variety of factors suggests that it may in fact not be the antibody that confers immunity to the disease. The phagocytic test does not appear promising as a technique for determining the effectiveness of a typhoid vaccine, but passive protection of the chick-embryo may warrant further investigation.
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