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  • Title: PROTEIN SYNTHESIS ENHANCED IN THE LIVER OF RATS FORCE-FED A THREONINE-DEVOID DIET.
    Author: SIDRANSKY H, STAEHELIN T, VERNEY E.
    Journal: Science; 1964 Nov 06; 146(3645):766-8. PubMed ID: 14197560.
    Abstract:
    There is enhanced incorporation of leucine-C(14) into proteins in cell-free preparations from livers of young rats force-fed a threonine-devoid diet for 3 days. This increased protein synthesis in the liver is related predominantly to enhanced activity of ribosomes. The aggregates of liver ribosomes (ergosonmes or polysomes) as measured in a sucrose gradient indicated a shift from lighter toward heavier ergosomes with a decrease in monomers.
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