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  • Title: Late onset Leber's optic neuropathy: a case confused with ischaemic optic neuropathy.
    Author: Borruat FX, Green WT, Graham EM, Sweeney MG, Morgan-Hughes JA, Sanders MD.
    Journal: Br J Ophthalmol; 1992 Sep; 76(9):571-3. PubMed ID: 1420066.
    Abstract:
    A case is reported of a 63-year-old man with progressive central visual loss in one eye followed 11 months later by involvement of the fellow eye. A diagnosis of chronic ischaemic optic neuropathy was considered. However, despite a negative family history, the absence of electrocardiographic abnormalities, and minimal fundus changes a diagnosis of Leber's optic neuropathy was made on the basis of magnetic resonance imaging findings and the mitochondrial DNA mutation at base pair 11778.
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