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  • Title: THE IMMUNOGLOBULINS OF MICE. II. TWO SUBCLASSES OF MOUSE 7S GAMMA-2-GLOBULINS: GAMMA-2A- AND GAMMA-2B-GLOBULINS.
    Author: FAHEY JL, WUNDERLICH J, MISHELL R.
    Journal: J Exp Med; 1964 Aug 01; 120(2):243-51. PubMed ID: 14206439.
    Abstract:
    Two subclasses of mouse 7S gamma(2)-globulins are identified, and are designated gamma(2a)- and gamma(2b)-globulins. They are distinguished from 7S gamma(1)-globulins, gamma(1A) (beta(2A))-globulins, and gamma(1M)-globulins of mouse serum. Antibody activity was detected among the gamma(2a)-globulins and gamma(2b)-globulins of hyperimmune mouse serum. gamma(2a)- and gamma(2b)-myeloma proteins were identified. The genetically determined isoantigen, Iga-1, was present on gamma(2a)-myeloma proteins, but not on gamma(2b)-myeloma proteins. These findings indicate a complexity among the 7S gamma(2)-globulins which must be taken into account in structural, functional, and genetic studies of immunoglobulins.
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