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  • Title: [Structural-metabolic changes in the ventricular myocardium in massive experimental pulmonary embolism].
    Author: Tverskaia MS, Karpova VV, Virganskiĭ AO, Banin VV, Tsareva LA, Satyl'ganov IZh, Rogulenko RV, Tikhvinskaia EI, Chumakova MA, Saganelidze IG.
    Journal: Biull Eksp Biol Med; 1992 Mar; 113(3):327-9. PubMed ID: 1421243.
    Abstract:
    A comparative study of hemodynamic and structural-metabolic changes in myocardium of right (RV) and left (LV) ventricles by compensative massive pulmonary embolism (MPE) and decompensated MPE was made in 29 mongrel dogs. By decompensated MPE the histoenzymological and ultrastructural methods reveal changes in RV which are not adequate to its high hemodynamic load: the catabolic enzymes activity decreases, the numeral density of mitochondrial profiles decreases too, the fraction of damaged mitochondria increases. By decompensated MPE the myocardial metabolism shifts from catabolic to biosynthetic processes, the activity of NADP.H-D and G-6-PDG increase in both ventricles.
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