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  • Title: [Analysis of the role of calcium in analgesic action of non-narcotic analgesics and calcium channel blockers].
    Author: Trinus FP, Kurskiĭ MD, Gubskiĭ IuI, Bukhtiarova TA.
    Journal: Biull Eksp Biol Med; 1992 May; 113(5):508-9. PubMed ID: 1421272.
    Abstract:
    In the mice hot-plate test we have compared analgesic effect of calcium channel blockers and new non-narcotic analgesic antiinflammatory agent PV-107: verapamil > fenigidin > PV-107. Simultaneously we have shown strong correlation (r - 0.82) between analgesic effect and 45Ca2+ efflux of cardiac membrane in depolarizing media in vitro.
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