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  • Title: [Inhibition of phospholipid reacylation in oxidative damage of tumor cells].
    Author: Kondakova IV, Borunov EV, Bondarenko EI.
    Journal: Biull Eksp Biol Med; 1992 May; 113(5):522-4. PubMed ID: 1421279.
    Abstract:
    In this study we examined the effect of oxidative stress on phospholipid reacylation and [1-14C]arachidonic acid uptake by murine mastocytoma P815 cells. Tert-butyl hydroperoxide inhibited arachidonic acid uptake by P815 cells and incorporation of fatty acid into main cellular phospholipids. Specific activity of control phosphatidylcholine was about 15-fold higher than that of phosphatidylcholine from tert-butyl hydroperoxide-treated cells. For phosphatidylethanolamine and phosphatidylinositol this inhibition was about 7-fold and 12-fold, respectively. Thus, oxidative stress causes the drastic changes in the process of phospholipid repair, which may significantly disorder membrane stability.
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