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  • Title: [The effect of a new drug form for the intravenous administration of vitamin K1 on the blood coagulation system].
    Author: Belozerskaia GG, Makarov VA, Petrukhina GN, Samoĭlov AV, Kamaev NO, Seĭfulla RD.
    Journal: Eksp Klin Farmakol; 1992; 55(2):33-4. PubMed ID: 1422449.
    Abstract:
    In rabbits with experimental hypocoagulation induced by phenylin, the use of a new dosage form of vitamin K1 for intravenous injections in does of 1 and 5 mg/kg led, in contrast to vicasol in a dose of 0.4 mg/kg, to an increase of the prothrombin index after 2 hours and to its complete normalization after 4 hours. Intravenous injection of vitamin K1 into intact animals did not entail any changes in the activated partial thromboplastin time, thrombin and prothrombin time, in the content of fibrinogen and products of its biotransformation, antithrombin III activity, and fibrinolytic activity or in the count of platelets and their aggregation capacity.
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