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  • Title: Uncouplers and the molecular mechanism of uncoupling in mitochondria.
    Author: Kessler RJ, Vande Zande H, Tyson CA, Blondin GA, Fairfield J, Glasser P, Green DE.
    Journal: Proc Natl Acad Sci U S A; 1977 Jun; 74(6):2241-5. PubMed ID: 142250.
    Abstract:
    Uncouplers are molecules with protonophoric and ionophoric capabilities that mediate coupled cyclical transport of cations--a transport that takes precedence over all other coupled processes. Uncouplers form cation-containing complexes with electrogenic ionophores that potentiate cyclical transport of cations. The molecular mechanism of uncoupling sheds strong light on the mechanism of coupling.
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