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  • Title: [Effects of hydroxythiamine and citrate on several reactions of the pentose phosphate cycle and glycolysis].
    Author: Trebukhina RV, Ostrovskiĭ IuM, Mikhal'tsevich GN, Borodinskiĭ AN, Lashak LK.
    Journal: Vopr Med Khim; 1977; 23(2):266-70. PubMed ID: 142370.
    Abstract:
    Hydroxythiamin was shown to inhibite distinctly phosphofructokinase and phosphohexoisomerase besides a direct antivitaminous effect on transketolase. In this case the regulatory action is likely to be carried out by erythrose-4-phosphate, accumulating in liver tissue. Citrate (administered separately and together with hydroxythiamin) is assumed to influence indirectly the transketolase activity affecting the total regulation of carbohydrate metabolism.
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