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  • Title: TRANSPLANTATION IMMUNITY OF GESTATIONAL ORIGIN IN INFANT RATS.
    Author: BILLINGHAM RE, PALM J, SILVERS WK.
    Journal: Science; 1965 Jan 29; 147(3657):514-6. PubMed ID: 14237209.
    Abstract:
    Comparison of the survival times of homografts of BN skin on 3-day-old Lewis rats born of mothers of the same isogenic strain with those of BN grafts on infant Lewis hosts that had developed in an F(1) (Lewis x BN) hybrid, gave no evidence of maternally induced tolerance as a result of development in an antigenically alien environment. On the contrary, the significantly shorter median survival time of the grafts on the hybrid-derived Lewis group suggests that sensitization had occurred as a consequence of natural exposure during gestation to small numbers of maternal cells.
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