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  • Title: Effect of Norplant-2 rods on haemostatic function.
    Author: Kuldip S, Viegas OA, Koh SL, Ratnam SS.
    Journal: Contraception; 1992 Jul; 46(1):71-81. PubMed ID: 1424625.
    Abstract:
    A longitudinal study on one-hundred Singaporean women using Norplant-2 rod implant for contraception and their effects on the haemostatic function was carried out. There was a decrease in vitamin K-dependent Factors II, VII and a tendency towards lowered fibrinolytic activity after prolong use of Norplant-2 rods. The results indicate that the Norplant-2 rod implant system does not contribute towards hypercoagulable state but increased platelets and accelerated platelet aggregation observed will require further study to ascertain whether there is a concomitant increase in platelet activation.
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