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  • Title: Inhibition of human corneal epithelium with immunotoxin 454A12-rRA.
    Author: Fulcher SF, Foulks GN, Wilkerson M, Cobo LM, Jaffe GJ, Hatchell DL.
    Journal: Cornea; 1992 Sep; 11(5):413-7. PubMed ID: 1424670.
    Abstract:
    We examined the effects of the immunotoxin 454A12-rRa on proliferating and confluent human corneal epithelium (HCE) in vitro. Proliferating HCE was sensitive to 454A12-rRA in a dose-dependent fashion. At immunotoxin concentrations of 1,000 ng/ml for 7 days we observed an 86% reduction in cell counts. Confluent HCE was not sensitive to 454A12-rRA at equivalent concentrations of immunotoxin. These data confirm previous observations regarding selective sensitivity of proliferating ocular tissue to immunotoxin, but suggest that HCE is less sensitive to 454A12-rRA than other ocular cell types.
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