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  • Title: [Quantitative model of human erythrocyte glycolysis. I. Relationship between the stationary rate of glycolysis and the ATP concentration].
    Author: Ataullakhanov FI, Vitvitskiĭ VM, Zhabotinskiĭ AM, Kholodenko BN, Erlikh LI.
    Journal: Biofizika; 1977; 22(3):483-8. PubMed ID: 142521.
    Abstract:
    A mathematical model is presented of the Embden--Meyerhof pathway in the human red blood cell. The rate of the system stationary flux is determined by the first part of the chain including three enzymatic reactions. The function has been calculated which describes the dependence of the stationary rate of glucose consumption and ATP production on the concentration of ATP. The curve has a bell shape with the physiological normal point situated in the descending segment. The descending segment is a result of the inhibition of the phosphofructokinase by ATP and the strong inhibition of the hexokinase by glucose-6-phosphate.
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