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  • Title: [Synthesis of ribosomal RNA in the lymphocytes with 21-chromosome trisomy].
    Author: Davidenkova EF, Shvarts EI, Chukhlovin AB, Rozenberg OA.
    Journal: Biull Eksp Biol Med; 1976 Oct; 82(10):1263-4. PubMed ID: 142530.
    Abstract:
    Normal and 21-trisomic lymphocytes isolated from whole blood were cultivated with phytohemagglutinin (PHA) for 21 hours and labeled with 3H-uridine. Polysomes were then extracted, using magnesium precipitation. The samples of polysome rRNA were disc-electrophoresed, and the specific activity of the 28S-RNA was determined. In spite of the decreased RNA-synthetic response of the 21-trisomic lymphocytes (determined earlier) the specific activity of the rRNA in the aberrant cells failed to differ from the normal. A decrease in the number of the PHA-responsive cells in the 21-trisomic lymphoid population is supposed.
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