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  • Title: VACCINIA VIRUS DIRECTED RNA: ITS FATE IN THE PRESENCE OF ACTINOMYCIN.
    Author: SHATKIN AJ, SEBRING ED, SALZMAN NP.
    Journal: Science; 1965 Apr 02; 148(3666):87-90. PubMed ID: 14260385.
    Abstract:
    RNA similar in base composition to viral DNA is formed in the cytoplasm of HeLa cells infected with vaccinia virus. This RNA is found both in polyribosomes and in a broad 30S to 74S region in a sucrose density gradient. When infected cells are exposed to actinomycin, the amount of this DNA-like RNA in the 30S to 74S region is unchanged. Under the same conditions, 70 percent of the polyribosome-associated DNA-like RNA is degraded to acidsoluble fragments within 2 hours, and protein synthesis is reduced by 90 percent.
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