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  • Title: CHROMATOGRAPHIC SEPARATION OF ANNEALED AND ENZYMATICALLY SYNTHESIZED RNA-DNA HYBRIDS.
    Author: HAYASHI MN, HAYASHI M, SPIEGELMAN S.
    Journal: Biophys J; 1965 Mar; 5(2):231-46. PubMed ID: 14268956.
    Abstract:
    A procedure is described for the chromatographic detection and isolation of DNA-RNA hybrids on columns of methylated albumin coated on kieselguhr (MAK). Its use is illustrated with both annealed and enzymatically synthesized hybrids. The method has the advantage of a wide range in capacity and resolution and permits actual isolation of the hybrid structure. It is uniquely effective in experiments involving hybridization with small DNA fragments.
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