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  • Title: Non-enzymatic glycosylation of myosin: effects of diabetes and ageing.
    Author: Syrový I, Hodný Z.
    Journal: Gen Physiol Biophys; 1992 Jun; 11(3):301-7. PubMed ID: 1426977.
    Abstract:
    The influence of diabetes mellitus, streptozotocin-induced diabetes and ageing on the non-enzymatic glycosylation of myosin from cardiac and skeletal muscles was investigated. In cardiac muscle, and to a lesser extent also in skeletal muscles of the rat, non-enzymatic glycosylation of myosin increases with the age, as measured in 6-, 12- and 29-month-old animals. Skeletal muscle myosin from diabetic humans and also that from diabetic rat cardiac muscle are more glycosylated when compared with control myosin preparations. Ca(2+)-ATPase activity of myosin is lower in muscles of diabetic individuals as compared with control muscles.
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