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  • Title: Analysis of clonality of tumour infiltrating lymphocytes in breast cancer and uveal melanoma.
    Author: Durie FH, George WD, Campbell AM, Damato BE.
    Journal: Immunol Lett; 1992 Aug; 33(3):263-9. PubMed ID: 1428001.
    Abstract:
    Fresh tumour infiltrating lymphocytes (TILs) from 6 uveal melanomas and 4 breast cancers were analysed by flow cytometry with a panel of 6 monoclonal antibodies to V beta regions of the T cell receptor (V betas 5a, 5b, 5c, 6, 8a and 12a). With a single exception where one TIL sample lacked V beta 12a, lymphocytes from both tumour and blood contained cells reactive with all 6 probes, and no probe was highly dominant or missing. The proportions of reactive cells differed between tumour and blood within each patient. The data indicate that while tumour infiltrating lymphocytes have a capacity to locate selectively within the tumour they nonetheless comprise a population expressing a diversity of TCR V beta genes.
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