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  • Title: GALLSTONES PRODUCED EXPERIMENTALLY BY LITHOCHOLIC ACID IN RATS.
    Author: PALMER RH.
    Journal: Science; 1965 Jun 04; 148(3675):1339-40. PubMed ID: 14281716.
    Abstract:
    Administration of lithocholic acid (1 percent in the diet) consistently produces choledocholithiasis in 8 weeks in rats on an 8-percent protein diet. The gallstones consist predominantly of the calcium salts of free and glycine-conjugated lithocholic and 3alpha,6beta-dihydroxy-5beta-cholanic acids. Conjugation of bile acid with taurine can be enhanced and stone formation can be inhibited by an increase in the dietary protein or by a diet supplemented with taurine.
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