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  • Title: Rapidly fatal Q-fever pneumonia in a patient with chronic granulomatous disease.
    Author: Meis JF, Weemaes CR, Horrevorts AM, Aerdts SJ, Westenend PJ, Galama JM.
    Journal: Infection; 1992; 20(5):287-9. PubMed ID: 1428185.
    Abstract:
    Acute Q-fever is a systemic illness which rarely has a fatal outcome. Fatal cases do occur with the chronic form of the disease and associated with endocarditis. This report presents the case of a fatal, acute Q-fever pneumonia in an 11-year-old patient with chronic granulomatous disease. Complement fixation antibody titer rose to 1:1,024 with positive IgM in immunofluorescence. Giemsa stained lung sections and indirect immunofluorescence demonstrated the microorganisms in the tissues. The Coxiella burnetii infection was probably contracted during a holiday trip to rural France. Despite the fact that the patient received a variety of antimicrobial agents with broad spectrum activity against bacteria and fungi, coverage for Q-fever, i.e. chloramphenicol or tetracyclines, was not included.
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