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  • Title: Butyrolactols A and B, new antifungal antibiotics. Taxonomy, isolation, physico-chemical properties, structure and biological activity.
    Author: Kotake C, Yamasaki T, Moriyama T, Shinoda M, Komiyama N, Furumai T, Konishi M, Oki T.
    Journal: J Antibiot (Tokyo); 1992 Sep; 45(9):1442-50. PubMed ID: 1429230.
    Abstract:
    New antifungal antibiotics, butyrolactols A and B, have been isolated from the culture broth of Streptomyces rochei S785-16. They are novel type of molecules containing a common 2,3-dihydroxybutyrolactone nucleus substituted with a different long hydroxyalkyl side chain. Butyrolactol A showed good antifungal activity against Aspergillus fumigatus and Trichophyton mentagrophytes, and moderately inhibited the growth of yeasts.
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