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  • Title: Uteroplacental blood flow and estrogen production following dehydroisoandrosterone infusion.
    Author: Rosenfeld CR, Worley RJ, Gant N.
    Journal: Obstet Gynecol; 1977 Sep; 50(3):304-7. PubMed ID: 142933.
    Abstract:
    The effects of systemic infusions of dehydroisoandrosterone on uterine blood flow and the plasma concentration of estrogen in ovine pregnancy were studied in 7 pregnant ewes 52 to 128 days of gestation. Uterine blood flow increased 17.8% after a systemic infusion of dehydroisoandrosterone of 4.67 mg +/- 0.3. Maximum blood flows occurred 111 min +/- 5.8 after injection of dehydroisoandrosterone. The increase in flow (milliliter/minute) was greatest after 100 days of gestation. Plasma estrone concentrations increased from 67.9 pg/ml to 201 pg/ml, while estradiol rose from 42.6 pg/ml to 115 pg/ml (P less than 0.001). Estriol was not detected.
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