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  • Title: [Antigen detection in the murine models of systemic candidiasis].
    Author: Mitsutake K, Kohno S, Matsuda H, Yoshitomi Y, Miyazaki Y, Higashiyama Y, Tanaka K, Iwamoto M, Maesaki S, Kaku M.
    Journal: Kansenshogaku Zasshi; 1992 Jun; 66(6):716-20. PubMed ID: 1431353.
    Abstract:
    We compared two latex agglutination tests for serum candidal antigen in murine models of systemic infection and gastrointestinal colonization. In the intravascular-infection model, mannan detection test was positive at 2 hours after inoculation, but Cand-Tec was less sensitive than mannan detection test in this model. In the gastrointestinal colonization model followed by systemic infection in neutropenic mice, the mannan antigen test became positive after 3 weeks of colonization with increased number of Candida of the stool, and Cand-Tec became positive after 5 weeks in neutropenic mice.
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