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  • Title: EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY.
    Author: BOREL Y, FAUCONNET M, MIESCHER PA.
    Journal: J Exp Med; 1965 Aug 01; 122(2):263-75. PubMed ID: 14316945.
    Abstract:
    In the primary response of mice and rabbits immunized with foreign red cells, 6-MP administration prolonged the formation of 19S antibody. 7S antibody formation was delayed and reduced in these animals. Animals treated with 6-MP during primary response exhibited a preferential 19S response when challenged in the anamnestic response. Animals immunized with small doses of antigen and treated with 6-MP only during the secondary response, reversed the usual antibody pattern and responded with preferential 19S antibody formation.
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