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  • Title: Brominated polyacetylenic acids from the marine sponge Xestospongia muta: inhibitors of HIV protease.
    Author: Patil AD, Kokke WC, Cochran S, Francis TA, Tomszek T, Westley JW.
    Journal: J Nat Prod; 1992 Sep; 55(9):1170-7. PubMed ID: 1431940.
    Abstract:
    The EtOAc extract of the sponge Xestospongia muta collected in Colombus Island, Bahamas, yielded eleven straight-chain unsaturated, polyacetylenic, brominated acids, seven of which were identified on the basis of spectral data, including the unknown acids 2-7. These acetylenic acids are the first known examples that have been shown to inhibit HIV protease, a critical enzyme in the replication of human immunodeficiency virus.
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