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  • Title: Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5.
    Author: Zhang L, Mohan PM, Padmanabhan R.
    Journal: J Virol; 1992 Dec; 66(12):7549-54. PubMed ID: 1433530.
    Abstract:
    Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution of the mature NS5.
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