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  • Title: [IL-5-and its receptor--the role of IL-5 in the development of hematopoietic cells in the long-term bone marrow cultures].
    Author: Katoh S, Takatsu K.
    Journal: Nihon Rinsho; 1992 Aug; 50(8):1795-801. PubMed ID: 1433970.
    Abstract:
    IL-5 is a T-cell-derived glycoprotein that acts on B cells and eosinophils to induce their growth and differentiation. We clarified using in vitro long-term bone marrow culture that IL-5 supports the growth and survival of Ly-1+ common progenitor cells which can differentiate into Ly-1+ B cells and Ly-1+ macrophages. The functional IL-5 receptor (IL-5R) consists of alpha and beta heterodimers. The 60 kDa alpha chain binds to IL-5 with low affinity, while the 130 kDa beta chain does not bind with IL-5 by itself, but converts low affinity IL-5R to high affinity IL-5R together with the alpha chain. The beta chain is shared with GM-CSFR and IL-3R.
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