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  • Title: Effect of ketotifen on acute gastric lesions and gastric secretion in rats.
    Author: Okabe S, Nakaji S, Tachibana M.
    Journal: Jpn J Pharmacol; 1992 Jun; 59(2):251-4. PubMed ID: 1434122.
    Abstract:
    Ketotifen, a histamine H1-receptor antagonist and mast cell stabilizer, significantly protected the rat gastric mucosa against lesions induced by necrotizing agents, histamine or compound 48/80. The agent significantly inhibited the basal gastric acid secretion, but had little or no effect on the histamine-stimulated secretion. The mucosal protective effect was observed even at a dose that had little or no effect on gastric acid secretion, suggesting that ketotifen exhibits so-called cytoprotective activity.
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