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  • Title: Analgesic, heart rate, and temperature effects of delta8-THC during acute and chronic administration to conscious rats.
    Author: Hine B, Toreelio M, Gershon S.
    Journal: Pharmacology; 1977; 15(1):63-72. PubMed ID: 14347.
    Abstract:
    Acute and chronic effects of delta8-THC on tail-flick, heart rate, and rectal temperature responses in conscious, unrestrained male rats were studied. In the acute experiment unidirectional dose-dependent analgesic, hypothermic, and negative chronotropic cardiac effects were observed within the dose range employed. Of the three variables, heart-rate decreases were most sensitive to the effects of THC, reaching significance at 2 mg/kg. Rapid development of tolerance occurred for all three measures, with complete tolerance developing within 13 days only to the heart-rate decreases. The results discussed in the context of previous data.
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