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  • Title: Autosomal dominant polycystic kidney disease complicated by glomerulonephritis.
    Author: Villar MT, Bass P, Dewhurst G, Theaker JM, Dathan JR.
    Journal: Nephron; 1992; 62(2):226-8. PubMed ID: 1436319.
    Abstract:
    Two patients with autosomal dominant polycystic kidney disease (ADPKD) and concurrent glomerulonephritis are described. Both developed nephrotic-range proteinuria and one showed a concomitant acceleration in the rate of decline of renal function. Subsequent open renal biopsy revealed membrano-proliferative type-1 and mesangio-proliferative glomerulonephritis, respectively. Nephrotic-range proteinuria in the presence of ADPKD, with or without an accompanying decline in renal function, should prompt further investigation to exclude coexisting glomerular disease.
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