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  • Title: Limited-spectrum (first-generation) cephalosporins.
    Author: Graham JM, Oshiro BT, Blanco JD.
    Journal: Obstet Gynecol Clin North Am; 1992 Sep; 19(3):449-59. PubMed ID: 1436923.
    Abstract:
    Except in the treatment of pyelonephritis, the first-generation cephalosporins are rarely the first line drug of choice for any suspected infection in obstetrics. Other antibiotics have a narrower spectrum of antimicrobial coverage and are cheaper. Unless culture dictates the use of cephalosporins for main-line therapy, the use of first-generation cephalosporins should be limited to the treatment of pyelonephritis in pregnancy and for prophylaxis at the time of surgery.
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