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  • Title: C3 fixed in vivo to cornea from horses inoculated with Leptospira interrogans.
    Author: Parma AE, Cerone SI, Sansinanea SA, Ghezzi M.
    Journal: Vet Immunol Immunopathol; 1992 Oct; 34(1-2):181-7. PubMed ID: 1441226.
    Abstract:
    C3 was detected bound in vivo to the opaque cornea of horses inoculated with killed Leptospira interrogans. Employing epithelial corneal cells isolated from a monolayer in tissue culture, we proved that C3 is fixed in vitro to the intact cell surface after incubation with a fresh equine anti-Leptospira serum. These findings, in addition to the infiltration of cornea with neutrophils and lymphocytes, may explain the mechanisms of tissue damage in recurrent uveitis of horses with leptospirosis.
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