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  • Title: [Use of the magnitude of vitamin and vitamin metabolite excretion as indicators of availability of vitamins B2, B6, and niacin].
    Author: Kodentsova VM, Vrzhesinskaia OA, Spirichev VB.
    Journal: Vopr Med Khim; 1992; 38(1):22-5. PubMed ID: 1441287.
    Abstract:
    Alimentary deficiency of riboflavin in rats caused a decrease in excretion of vitamin B2 with urine simultaneously with lowering in daily excretion of 4-pyridoxylic acid (4-PA) and N1-methyl nicotinamide (N1-MNA); these patterns are usually used as indicators of pyridoxine and niacin availability. The similar decrease in excretion of 4-PA and N1-MNA with urine but without alterations in NAD+NADP concentrations in erythrocytes was detected in women deficient in vitamin B2. Content of nicotinamide coenzymes in erythrocytes correlated with excretion of N1-MNA with urine only under normal conditions of riboflavin availability. Use of the criteria involving rates of 4-PA and N1-MNA excretion for evaluation of pyridoxine and niacin deficiency is discussed.
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