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  • Title: [Monoclonal antibodies to the influenza A virus matrix protein that react with viral strains of different subtypes].
    Author: Popov IA, Chervonskiĭ AV, Krivoshein IuS, Krivorutchenko IuL, Bakova AA, Fedorkina OA.
    Journal: Vopr Virusol; 1992; 37(3):141-4. PubMed ID: 1441439.
    Abstract:
    To obtain hybridomas secreting monoclonal antibodies (MCA) to matrix (M) protein of influenza virus, mice were immunized with a modified antigen which consisted of subvirus units after electrophoretic removal of surface glycoproteins from virions using Desintegnon-O detergent. Six stable hybrid cultures producing MCA to M-protein were derived. The properties of MCA to the antigen determinant common for a group of influenza A virus strains of different subtypes allow them to be used in the development of a test-system for diagnosis of influenza A type.
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