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  • Title: [Total synthesis of securinine].
    Author: Xi FD, Liang XT.
    Journal: Yao Xue Xue Bao; 1992; 27(5):349-52. PubMed ID: 1442055.
    Abstract:
    Securinine, an alkaloid having strychnine-like action was synthesized using 1,4-cyclohexanedione as the starting material through the following sequence of reactions: condensation with piperidine, reduction, cyclization catalyzed by mercuric acetate and intramolecular condensation, totally in eleven steps. The IR, 1HNMR and melting point of the synthetic product is identical with those of natural securinine.
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