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  • Title: Effects of insulin and phorbol esters on subcellular distribution of protein kinase C isoforms in rat adipocytes.
    Author: Farese RV, Standaert ML, Francois AJ, Ways K, Arnold TP, Hernandez H, Cooper DR.
    Journal: Biochem J; 1992 Nov 15; 288 ( Pt 1)(Pt 1):319-23. PubMed ID: 1445277.
    Abstract:
    Effects of insulin and phorbol esters on subcellular distribution of protein kinase C (PKC) isoforms were examined in rat adipocytes. Both agonists provoked rapid decreases in cytosolic, and/or increases in membrane, immunoreactive PKC-alpha, PKC-beta, PKC-gamma, and PKC-epsilon. Effects of phorbol esters on PKC-alpha redistribution to the plasma membrane, however, were much greater than those of insulin. In contrast, insulin, but not phorbol esters, stimulated the translocation of PKC-beta to the plasma membrane, and provoked changes in PKC-zeta redistribution. Neither agonist altered subcellular distribution of PKC-delta, which was detected only in membrane fractions. Our findings indicate that insulin and phorbol esters have overlapping and distinctly different effects on the subcellular redistribution of specific PKC isoforms.
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