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  • Title: Effect of endotoxin on rat liver regeneration after partial hepatectomy.
    Author: Tsukamoto I, Nakata R, Kojo S.
    Journal: Biochem Int; 1992 Sep; 27(6):1047-50. PubMed ID: 1445372.
    Abstract:
    Lipopolysaccharide administered intraperitoneally to rats just after partial (70%) hepatectomy at the dose from 0.04 to 4 mg/kg body weight inhibited the induction of thymidylate synthase and thymidine kinase which are rate-determining enzymes of DNA synthesis, resulting in the impairment of DNA synthesis in the regenerating liver. This effect may be due to the hepato-toxic nature of endotoxin.
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