These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of polyene antibiotics on protoplasts of Neurospora crassa.
    Author: KINSKY SC.
    Journal: J Bacteriol; 1962 Feb; 83(2):351-8. PubMed ID: 14456209.
    Abstract:
    Kinsky, Stephen C. (Washington University, St. Louis, Mo.). Effect of polyene antibiotics on protoplasts of Neurospora crassa. J. Bacteriol. 83:351-358. 1962.-The polyene antibiotics nystatin, amphotericin B, and filipin induced shrinkage of Neurospora crassa protoplasts stabilized in sucrose. At low concentrations of filipin (5 mug per ml), or higher concentrations of nystatin and amphotericin B (20 mug per ml), shrinkage was followed by swelling and lysis (bursting) of protoplasts. The effect of various parameters, such as metabolic inhibitors, protoplast concentration, and polyene concentration, was determined. The available evidence is consistent with the hypothesis that polyene antibiotics act by altering cellular permeability, possibly by reaction with the cell membrane, of sensitive organisms.
    [Abstract] [Full Text] [Related] [New Search]