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  • Title: The relation between molecular weight of antigen and ability to elicit passive cutaneous anaphylaxis.
    Author: LESKOWITZ S, OVARY Z.
    Journal: Immunology; 1962 Jan; 5(1):1-10. PubMed ID: 14464304.
    Abstract:
    Passive cutaneous anaphylaxis in the guinea pig has been studied with rabbit antibody to a series of antigens of differing molecular weight. The results indicated that at a given antibody level the weight of antigen needed to elicit a reaction increases with its molecular weight. Previous observations have been confirmed that the amount of antigen needed to elicit a reaction at a high level of antibody is less than that required at a lower level. The results suggest that extremely small amounts of small molecular weight antigens might be sufficient to produce anaphylactic symptoms in highly sensitive individuals.
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