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  • Title: Gamma-pyrone compounds. II: Synthesis and antiplatelet effects of tetraoxygenated xanthones.
    Author: Lin CN, Liou SS, Ko FN, Teng CM.
    Journal: J Pharm Sci; 1992 Nov; 81(11):1109-12. PubMed ID: 1447715.
    Abstract:
    Norathyriol and its analogues, 1,3,5,6-, 3,4,5,6-, 3,4,6,7- and 2,3,6,7-tetrahydroxyxanthone, were synthesized from benzophenone precursors by Friedel-Crafts acylation and subsequent base-catalyzed cyclization to eliminate methanol. Both 3,4,6,7- and 2,3,6,7-tetrahydroxyxanthone tetraacetate showed potent anti-platelet aggregation effects on arachidonic acid-induced platelet aggregation. 3,4,6,7-Tetrahydroxyxanthone tetraacetate and 1,3,5,6-tetrahydroxyxanthone showed potent and significant anti-platelet aggregation effects on collagen-induced platelet aggregation.
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