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  • Title: [Catalytic effect of gamma-thrombin on synthetic low molecular weight peptide substrates].
    Author: Shvachko LP, Poiarkova SA, Kostiuchenko NV, Kibirev VK.
    Journal: Ukr Biokhim Zh (1978); 1992; 64(4):34-7. PubMed ID: 1448872.
    Abstract:
    Hydrolysis and respective catalytic parameters of hydrolysis of ester peptide substrates that contain residues of hydrophobic and nonpolar amino acids in P2, P3 subsites have been studied. It is shown that efficiency of hydrolysis by thrombin is determined by the length of polypeptide chains and by the nature of the amino acids in P2, P3 subsites in the substrate. In spite of the fact that gamma-thrombin retains the conformation activity of the catalytic centre the local conformation changes of the second binding region of the enzyme have been discovered.
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