These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Non-quantal release of transmitter at mouse neuromuscular junction and its dependence on the activity of Na+-K+ ATP-ase.
    Author: Vyskocil F, Illés P.
    Journal: Pflugers Arch; 1977 Sep 16; 370(3):295-7. PubMed ID: 144899.
    Abstract:
    The postjunctional membrane of mouse diaphragm fibres was hyperpolarized by 1-2 mV during local curarization of the end-plate zone in the presence of anticholinesterase. In a solution containing 5 mM K+, the mean hyperpolarization was 1.0+/-0.35 mV. Hyperpolarization was 1.46+/-0.30 mV when the activity of the Na-K pump was blocked by 2 x 10(-5) M ouabain and 1.82+/-0.43 mV when it was blocked by bathing the muscle in a K+-free medium. Reactivation of membrane ATP-ase by addition of potassium after a period in K+-free medium reduced the hyperpolarization to zero, when measurements were made 10-20 min after the readdition. It is concluded that spontaneous non-quantal leakage of acetylcholine occurs at the mouse neuromuscular junction, as it does in the frog (2). Conditions which block the Na+-k+-dependent ATPase increased the leakage whereas potentiation of the pump activity decreased it.
    [Abstract] [Full Text] [Related] [New Search]